Women HealthHormone Replacement Therapy: A Guide to Continuous Combined HRT

Hormone Replacement Therapy: A Guide to Continuous Combined HRT


Share post:

What is continuous combined HRT?

Continuous combined hormone replacement therapy (HRT) is a treatment regimen used to alleviate symptoms associated with menopause by replacing hormones that the body no longer produces in sufficient quantities. Unlike cyclical HRT, where estrogen is taken daily, and progestin is added for a portion of the month to mimic the menstrual cycle, continuous combined HRT involves taking both estrogen and progestin continuously throughout the month.

Who is it suitable for?

Continuous combined HRT may be suitable for women experiencing menopausal symptoms such as hot flashes, night sweats, vaginal dryness, and mood swings. It can also benefit those at risk of osteoporosis due to decreased estrogen levels. However, not all women are suitable candidates. Factors such as age, medical history, and individual symptoms should be considered. Women with a history of certain cancers, blood clots, or cardiovascular disease may need alternative treatments. It’s essential to consult with a healthcare professional to determine suitability.

Types of continuous combined HRT

Continuous combined HRT typically involves the use of both estrogen and progestin hormones. Estrogen can be administered in various forms, including pills, patches, gels, sprays, or vaginal rings. Progestin is often taken orally, but it may also be administered through patches or intrauterine devices (IUDs). The choice of hormone type and delivery method depends on individual preferences, medical history, and the severity of menopausal symptoms.

Benefits and risks

Continuous combined HRT offers several benefits, including relief from menopausal symptoms, improved bone health, and reduced risk of fractures. It can also help maintain vaginal and urinary tract health. However, HRT carries potential risks, including an increased risk of blood clots, stroke, heart disease, and breast cancer. The decision to undergo HRT should be made after weighing the potential benefits against the risks and considering individual health factors.

Considerations before starting HRT

Before starting continuous combined HRT, it’s crucial to undergo a thorough medical evaluation and discuss individual health risks and concerns with a healthcare professional. Factors such as family history, personal medical history, lifestyle factors, and preferences should be considered. Regular monitoring and follow-up appointments are essential to assess the effectiveness of treatment and address any emerging issues.

Factors to consider when choosing continuous combined HRT

When choosing continuous combined HRT, several factors should be considered, including the type of hormones used, dosage strength, delivery method, and potential side effects. Individual preferences, lifestyle factors, and convenience also play a role. Consulting with a healthcare provider can help determine the most suitable option based on individual needs and health considerations.

Popular continuous combined HRT options

Several well-known and reputable brands offer continuous combined HRT products. These include but are not limited to:

Prempro: A combination of conjugated estrogens and medroxyprogesterone acetate available in pill form.

Climara Pro: A transdermal patch delivering estradiol and levonorgestrel continuously through the skin.

Activella: A combination tablet containing estradiol and norethindrone acetate for oral administration.

Each of these products has its own unique features and benefits, so it’s essential to discuss options with a healthcare provider to determine the most suitable choice.

Where to get continuous combined HRT

Continuous combined HRT is typically obtained through a prescription from a healthcare provider. Patients can discuss their symptoms and treatment options with their primary care physician, gynecologist, or menopause specialist. Additionally, some online pharmacies may offer HRT products, but caution should be exercised to ensure the legitimacy and safety of these sources.

Cost and insurance coverage

The cost of continuous combined HRT can vary depending on the specific product, dosage, and insurance coverage. Generic versions of HRT medications may be more affordable than brand-name options. Some insurance plans may cover part or all of the cost of HRT, but coverage policies vary, so it’s essential to check with your insurance provider to understand your benefits and potential out-of-pocket expenses.

Reviews and comparisons

User reviews and comparisons of different continuous combined HRT options can provide valuable insights into the effectiveness, side effects, and overall satisfaction with specific products. Online forums, patient advocacy groups, and healthcare websites may offer reviews and comparisons to help individuals make informed decisions about their treatment options. Additionally, healthcare providers can offer personalized recommendations based on individual health needs and preferences.


Continuous combined hormone replacement therapy can be an effective treatment option for menopausal symptoms and associated health concerns. However, it’s essential to weigh the potential benefits and risks, consult with a healthcare professional, and choose the most suitable option based on individual needs and preferences. With proper guidance and monitoring, continuous combined HRT can help women navigate the challenges of menopause and improve their quality of life.


What are the examples of sequential combined HRT?

Sequential combined HRT examples include regimens where estrogen is taken every day, and progesterone is added for a portion of the cycle, typically the last 10 to 14 days.

Is sequential or continuous HRT better?

The choice between sequential and continuous HRT depends on individual health needs and preferences. Sequential HRT mimics the natural menstrual cycle, while continuous HRT provides a steady hormone level. Both have benefits and risks.

Can I take progesterone continuously?

Yes, continuous progesterone therapy is an option, particularly for women who have had a hysterectomy and do not need estrogen. It can help alleviate symptoms and provide protection against endometrial hyperplasia. However, it’s essential to discuss with your healthcare provider to determine the most suitable approach for you.

Related topics:

latest articles

Related articles

Stress Rash How to Get Rid Of?

Clear and Accurate Information What is a Stress Rash? A stress rash is a type of skin reaction triggered by...

Understanding & Treating Stress Hives: A Comprehensive Guide

What Are Stress Hives? Stress hives, also known as urticaria, are raised, itchy welts that appear on the skin...

What is Scleroderma: A Comprehensive Guide

Scleroderma is a complex and often misunderstood condition. This article aims to provide a detailed overview of scleroderma,...

Analyzing Sexual and Reproductive Health and Rights in Arab States’ Climate Commitments: A Comprehensive Review

As nations strive to combat climate change, their commitments outlined in the Nationally Determined Contributions (NDCs) serve as...